PRiSM AI reads the retinal images your clinic already captures, combines them with each patient's health record, and stratifies systemic wellness risk so care teams can reach the right patients sooner. Wellness-oriented and non-diagnostic.
The retina is the only place in the body where blood vessels and nerve tissue are directly visible without surgery. Most clinical workflows stop at an ocular grade — missing early signals of systemic disease that were always there.
The leading cause of death globally. Retinal microvascular changes mirror early coronary and cerebrovascular damage — years before a cardiac event.
$2 trillion global burden by 2050 · AHA/Circulation 2024Nine in ten patients with CKD are unaware of their condition. Retinal vascular changes are among the earliest measurable indicators of renal decline.
9-in-10 unaware · CDC/USRDSOver 120 million American adults live with hypertension — the majority undertreated. The retina reflects arterial stiffness and hemorrhagic risk directly.
120M adults affected · CDC 2024PRiSM registers fundus, OCT, angiography, and OCTA images into a single structured map of the eye — then reads interpretable structural and vascular features from that map, rather than an opaque image score.
Those signals are fused with each patient's history, medications, labs, and lifestyle to build a personalized, wellness-oriented risk picture — separating patients who look alike on a standard grade, tracking whether risk is rising or falling, and pointing care teams to the people who need attention first.
The images your clinic already captures become a clear, actionable read on systemic risk.
Fundus, OCT, angiography, and OCTA images from standard clinical devices — alongside the patient's health record. One modality or several.
Normalize and align the images into a single, shared model of the retina so every finding lines up to the same anatomy across visits and modalities.
Extract interpretable retinal features — vessel calibre, blood flow, leakage, tissue structure — and cross-check against clinical knowledge before any risk scoring.
Fuse retinal signals with patient context — history, medications, labs, lifestyle — to produce personalized systemic risk, a trajectory over time, and clear next steps.
Patients with diabetes, hypertension, and kidney disease receive retinal exams because the retina offers a rare, direct view of the body's blood vessels and nerve tissue. Most workflows stop at an ocular grade — so two patients with the same retinopathy stage can leave with the same follow-up while carrying very different systemic risk.
PRiSM's patented method registers fundus, OCT, angiography, and OCTA images into a single anatomical map of the eye, then reads interpretable structural and vascular features from that map — vessel calibre, blood flow, leakage patterns, tissue structure — rather than an opaque image classification score.
PRiSM cross-checks those features against clinical knowledge, then fuses them with each patient's history, medications, labs, and lifestyle to build a personalized, wellness-oriented risk picture. The system separates patients who look alike on a standard grade, tracks whether risk is rising or easing across visits, and identifies the people care teams need to reach first.
It runs on the retinal cameras and scanners clinics already own — with one imaging modality or several — fitting into existing clinical workflow without new capital investment.
Fundus, OCT, fluorescein angiography, and OCTA images normalized and co-registered to a shared anatomical retinal model.
Named, clinically meaningful features — not black-box scores — so every risk assignment can be explained and audited.
Retinal signals joined to medical history, medications, labs, and lifestyle for a personalized systemic risk profile.
Tracks whether a patient's risk is rising or easing across visits — not a single point-in-time grade.
Runs on standard clinical devices already in the clinic — no new equipment or capital investment required.
Conceptual illustration only. Specific methods, algorithms, and system architecture are protected by patent pending status and trade secret law. The outputs of this platform support care decisions and are not a medical diagnosis.
Click a sample retinal scan and watch the agent analyze, stratify, and generate clinical guidance in real time. Synthetic data only — no patient information.
Open the Live DemoAn interdisciplinary team of clinicians, researchers, and engineers building non-invasive preventative medicine at the intersection of retinal imaging and AI.
Systemic vascular risk intelligence should be accessible through the routine eye exam — no expensive new equipment, no specialist referrals, no delayed diagnosis. PRiSM works with hardware clinics already own.
Catching risk before symptoms is not aspirational — it is an engineering problem. PRiSM's platform identifies who needs attention now, not who already had an event, shifting care from reactive to genuinely preventative.
Clinical insights only improve outcomes if they reach the right people. PRiSM routes risk stratification directly into existing EHR workflows — fitting clinical practice as it is, not as a research environment imagined it.